Low Dose Medicine: theoretical background and scientific evidence

Introduction The paper recently published by Carello R. et al. Long-term treatment with Low Dose Medicine in chronic childhood eczema. A double-blind two-stage randomized clinical trial (IJP 2017 43:78) highlights a new possible therapeutic approach for the treatment of chronic childhood eczema. It is based on the oral administration of low doses activated interleukin 12 and Interferon-γ in order to restore the immunologic balance, altered in the disease. This short commentary will briefly describe the theoretical background of Low Dose Medicine (LDM), with particular focus on the aspects linked with the efficacy and the safety of the LDM treatment.